The South / Southwest
From the San Francisco Bay Area (including San Francisco International Airport):
Take Highway 101 North to the Bay Bridge to I-80 East. From I-80 East, connect to I-505 North toward Redding and eventually, connect to I-5 North, which will bring you into the heart of Siskiyou.
Total drive time: Approximately 5 hours
From the Sacramento region (including Sacramento International Airport)
Take I-5 North all the way from Sacramento to Siskiyou.
Total drive time: Approximately 4 hours